Bernard Sachs (1858-1944)
نویسنده
چکیده
Bernard Sachs studied nervous system disorders in children in the United States during the nineteenth and twentieth centuries. In the late 1880s, Sachs described the fatal genetic neurological disorder called amaurotic family idiocy, later renamed Tay-Sachs disease. The disorder degrades motor skills as well as mental abilities in affected individuals. The expected lifespan of a child with Tay-Sachs is three to five years. In addition to working on Tay-Sachs disease, Sachs described other childhood neurological and developmental disorders that stem from problems with early brain development. Sachs's research in early brain development helped establish some of the physiological symptoms of hereditary neurological disorders in children, enabling doctors to diagnose the disorders earlier and to develop treatments for them.
منابع مشابه
Hereditary disease and its control.
Waren Tay was born in 1843; he qualified in medicine at the London Hospital and was appointed to it as a surgeon. He was also on the staff of the Royal London Ophthalmic Hospital at Moorfields and City Road, and the North East Hospital for Children, which became Queen Elizabeth Hospital, Hackney Road. A versatile man, he was also dermatologist to the Hospital for Diseases of the Skin. In 1881 h...
متن کاملThe conceptualization and organization of the first International Neurological Congress (1931): the coming of age of neurology.
The first International Neurological Congress (Berne, Switzerland, 1931), attended by individuals from 42 countries, signified a global presence of world neurology; a coming of age. The aim of this study was to trace the history of that Congress, an important episode in the emergence of our discipline. The historical literature was reviewed and a detailed study conducted of the Henry Alsop Rile...
متن کاملUlcerating Granuloma of Pudenda-treatment by Zinc Peroxide Paste.
McDermott, E. B., and Marcus, S. (1941) Amer. J. Syph., 25, 162. Mazzini, L. Y. (1939) Amer. J. clin. Path., 9, 163. (1942) Vener. Dis. Inform., 23, 123. Parran, T., Hazen, H. H., Mahoney, J. F., Sanford, A. H., Senear, F. E., Simpson, W. M., and Vonderlehr, R. A. (1942) Vener. Dis. Inform., 23, 161. Sachs, H. (1942) Brit. J. vener. Dis., 18, 96. Wyler, E. J. (1929) Spec. Rep. Ser. med. Res. Co...
متن کاملHeterozygote Screening in Tay-sachs Disease
In 1887, Bernard Sachs reported on the clinical features diagnostic signs and symptoms and pathology of a patient with a condition that would someday bear his name(l). It was several decades later before it was discovered that these patients suffered from a recessive genetic trait resulting in the accumulation of a specific ganglioside, GM2, due to the deficiency of the lysosomal enzyme hexosam...
متن کاملGeometric properties of multivariate correlation in de Finetti’s approach to insurance theory
We provide proofs and commentary on parts of Bruno De Finetti’s paper ”About Correlation”. In particular we focus on De Finetti’s angle theorem, which he stated without proof and whose striking simplicity and power would seem to make it a natural candidate for any multivariate statistics text. We establish a connection between de Finetti’s angle theorem and ongoing research on the boundary of t...
متن کامل